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Whatever few studies reported in this context advocate that GPx2 and GPx4 rather than GPx1 (major isozyme) may play a dominant role in conferring the organ-specific radioresistance [54,55,56, 67]

These are preclinical findings, not human clinical proofs

however, it seems unlikely that they had a similar bias against APAP

In this study, we have summarized the mechanisms of therapeutic agents in combination for cancer therapy, nanoscale carriers for co-delivery, drug-loading strategies, and controlled/targeted co-delivery systems, aiming to give a general picture of these powerful approaches for future NCDS research studies